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Now that I have more information about chronic hepatitis B, I can better understand my condition.*

Please see Indication and Important Safety Information below, including Boxed WARNINGS.

Not an actual patient.

Not an actual patient quote.

“Now that I have more information about chronic hepatitis B, I can better understand my condition.*

Please see Indication and Important Safety Information below, including Boxed WARNINGS.

Not an actual patient.

Not an actual patient quote.

Glossary

It can be hard to keep up with all of the different words used to explain chronic hepatitis B. Here's a helpful list of definitions:

ALT (alanine aminotransferase): A type of liver enzyme. High levels of this enzyme may indicate liver damage. It is recommended that someone with chronic hepatitis B get their ALT checked regularly.

AFP (alpha-fetoprotein): A protein released into the blood when cancer cells are present. Increased levels may indicate liver cancer. It is recommended that someone with chronic hepatitis B get tested for AFP regularly.

AST (aspartate aminotransferase): An enzyme produced in the liver. When liver cells are damaged, AST is released into the bloodstream. Elevated levels of AST may be an indication of liver disease. It is recommended that someone with chronic hepatitis B have his/her AST tested regularly.

Antibody: A protein that your immune system makes in response to a foreign substance such as a virus. Antibodies can be produced in response to a vaccine or a natural infection. Antibodies usually protect you against future infections.

Antigen: Any substance — either foreign or produced by the body — that causes the immune system to reproduce antibodies against it.

Antiviral therapy: A medicine that either kills the viruses or blocks steps in the process through which viruses reproduce.

Asymptomatic: A term that refers to a disease or infection with no signs of illness. People with the hepatitis B virus often show no symptoms of infection, but the virus can still be multiplying in the body and damaging the liver for years.

Biopsy: The removal of a sample of tissue from the body so that it can be examined for signs of damage or disease. (See liver biopsy)

Bloodborne pathogens: Substances in the blood that can cause infection or disease. The hepatitis B and hepatitis C viruses are both bloodborne pathogens. They are spread through blood and infected bodily fluids and can cause infection of the liver.

Chronic hepatitis B (CHB): A condition that occurs when one is infected with hepatitis B virus for more than 6 months. Often referred to as a "silent" disease, the virus infects the liver, damaging it over time, often without any symptoms.

Cirrhosis: A serious condition in which scarring and hardening of the liver occurs. Cirrhosis can cause your liver to stop working properly or to shut down altogether.

e-Antibody (HBeAb or anti-HBe): This antibody is made in response to the e-antigen and is detected in patients who have recovered from hepatitis B infections as well as those who are chronically infected.

Enzyme: A protein that speeds up a chemical change in other substances without changing itself.

Fibrosis (hepatic): Formation of fibrous tissue in the liver. Hepatic fibrosis usually occurs where there has been liver damage.

Gastroenterologist: A doctor who specializes in disorders of the gastrointestinal system. This includes the esophagus, stomach, pancreas, intestines, and liver.

HBV DNA (also called viral load) test: A test that measures the amount of hepatitis B virus in your blood and can indicate active viral replication.

Hepatitis A: This is an acute infection caused by the hepatitis A virus. Hepatitis A and Hepatitis B are different. Hepatitis A is spread mainly via feces and contaminated food and water, and most patients recover completely within 6 to 10 weeks.

Hepatitis B: A liver infection caused by the hepatitis B virus (HBV). It is spread primarily through infected blood and bodily fluids, unprotected sex, shared needles, and from infected mother's blood to her baby during birth.

Hepatitis B blood panel: A three-part blood test that helps your doctor diagnose hepatitis B. This test is made up of the following:

  • The hepatitis B surface antigen (HBsAg). If positive, then hepatitis B virus is in your body.
  • The hepatitis B surface antibody (HBsAb) test reveals whether or not your body has developed a protective antibody against the hepatitis B virus. Surface antibodies can form if you have been vaccinated, or if you have recovered from a hepatitis B infection. This usually provides long-term protection against future hepatitis B infection.
  • The hepatitis B core antibody (HBcAb) test reveals if you have been exposed to the virus. This antibody does not protect you from the hepatitis B virus.

Hepatitis B flare: A sharp increase in liver function tests to more than 10 times the ULN (upper limit of normal) and more than twice the starting level.

Hepatitis B Immune Globulin (HBIG): A medication given after a person has been exposed to potentially HBV-infected blood or infected bodily fluids, which can include: contact with blood, shared needles, infants born to infected women, and through sexual contact or close household contact with an infected person. HBIG is often used as a post-liver transplant treatment.

Hepatitis B virus (HBV): A type of virus that infects the liver, and may damage it over time. The virus can be transmitted from mother to child during childbirth. It can also be spread through unprotected sex, IV drug use, needle sharing, and contact with infected blood, semen, vaginal, and other bodily fluids.

Hepatocyte: A liver cell.

Hepatologist: A doctor who focuses on diseases of the liver.

Inflammation: A way in which the body reacts to infection, irritation, or other injury. Inflammation in most parts of the body may cause pain, redness, swelling, and warmth. However, an inflamed liver may cause no discomfort.

Jaundice: A yellowing of the skin and eyes that requires immediate medical attention. Jaundice can be a symptom of many conditions, including viral hepatitis, alcoholism, and poisoning, among others.

Lactic acidosis: A serious condition that occurs when lactic acid builds up in the blood. Lactic acidosis is a medical emergency that can lead to death and must be treated in the hospital.

Liver: The largest internal organ in the body. The liver performs many important tasks to keep the body healthy. It removes harmful toxins from the blood and helps digest food by turning it into energy and nutrients the body can use.

Liver biopsy: The removal of a small piece of tissue from the liver using a special needle. The tissue is examined under a microscope to look for the presence of inflammation or liver damage.

Scarring: Scar tissue can form in the liver as a result of injury or long-term disease. It can replace healthy tissue and partially block the flow of blood. Over time, this can cause your liver to stop working the way it should.

Ultrasound: An imaging test that uses the reflection of high-frequency sound waves to show pictures of organs inside the body. An ultrasound may help your doctor to see abnormalities on the surface of your liver.

Viral load: The amount of virus in the blood. The viral load is measured through a simple blood test.

Virus: A tiny microorganism that invades living cells and may cause diseases.

Starter Brochure

Read “Getting Started,” a helpful guide for patients taking BARACLUDE® (entecavir).

CLICK to download brochure

Questions to Ask Your Doctor

When it comes to managing chronic hepatitis B, you and your doctor are a team. Here are some questions to get you started.

CLICK to download questions brochure

Important Safety Information:

Selected Important Safety Information

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What is the most important information I should know about BARACLUDE® (entecavir)?

  •   Your hepatitis B virus infection may get worse if you stop taking BARACLUDE. This usually happens within 6 months after stopping BARACLUDE. Take BARACLUDE exactly as prescribed; do not run out of your medicine or stop taking BARACLUDE without talking to your healthcare provider. Your healthcare provider should monitor your health and do regular blood tests to check your liver if you stop taking BARACLUDE.
  •   If you have or get HIV infection that is not being treated with medicines while taking BARACLUDE, the HIV virus may develop resistance to certain HIV medicines and become harder to treat. You should get an HIV test before you start taking BARACLUDE and anytime after that when there is a chance you were exposed to HIV.

BARACLUDE can cause serious side effects including:

  •   Lactic acidosis (buildup of acid in the blood). Some people who have taken BARACLUDE or medicines like BARACLUDE have developed a serious condition called lactic acidosis. Lactic acidosis is a serious medical emergency that can cause death and must be treated in the hospital. Reports of lactic acidosis with BARACLUDE generally involved patients who were seriously ill due to their liver disease or other medical condition.
    •   Call your healthcare provider right away if you: feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; have stomach pain with nausea and vomiting; feel cold (especially in your arms and legs); feel dizzy or light-headed; have a fast or irregular heartbeat.
  •   Serious liver problems. Some people who have taken medicines like BARACLUDE have developed serious liver problems called hepatotoxicity, with liver enlargement (hepatomegaly) and fat in the liver (steatosis). Hepatomegaly with steatosis is a serious medical emergency that can cause death.
    •   Call your healthcare provider right away if: your skin or the white part of your eyes turns yellow (jaundice); your urine turns dark; your bowel movements (stools) turn light in color; you don’t feel like eating food for several days or longer; you feel sick to your stomach (nausea); you have lower stomach pain.
  •   If you are female, very overweight, or have been taking nucleoside analogue medicines, like BARACLUDE for a long time, you may be more likely to get lactic acidosis or serious liver problems.

Before you take BARACLUDE, tell your healthcare provider if you:

  •   have kidney problems. Your BARACLUDE dose or schedule may need to be changed.
  •   have received medicine for HBV before. Some people, especially those who have already been treated with certain other medicines for HBV, may develop resistance to BARACLUDE and may have less benefit from treatment. Your healthcare provider will test the level of the hepatitis B virus in your blood.
  •   have any other medical conditions.
  •   are pregnant or plan to become pregnant. It is not known if BARACLUDE will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.
  •   are breast-feeding or plan to breast-feed. It is not known if BARACLUDE can pass into your breast milk. You and your healthcare provider should decide if you will take BARACLUDE or breast-feed.

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

The most common side effects of BARACLUDE include: headache, tiredness, dizziness, and nausea. These are not all the possible side effects of BARACLUDE. For more information, ask your healthcare provider or pharmacist.

Do not change your dose or stop taking BARACLUDE without talking to your healthcare provider. If you forget to take your dose, call your healthcare provider or pharmacist, if you are not sure what to do.

Please see Full Prescribing Information, including “What is the most important information I should know about BARACLUDE?” in the Patient Information section. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Selected Important Safety Information:

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Selected Important Safety Information

Before you take BARACLUDE, tell your healthcare provider if you:

  •   have kidney problems. Your BARACLUDE dose or schedule may need to be changed.
  •   have received medicine for HBV before. Some people, especially those who have already been treated with certain other medicines for HBV, may develop resistance to BARACLUDE and may have less benefit from treatment. Your healthcare provider will test the level of the hepatitis B virus in your blood.
  •   have any other medical conditions.
  •   are pregnant or plan to become pregnant. It is not known if BARACLUDE will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.
  •   are breast-feeding or plan to breast-feed. It is not known if BARACLUDE can pass into your breast milk. You and your healthcare provider should decide if you will take BARACLUDE or breast-feed.

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.