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My doctor says that BARACLUDE may improve the condition of my liver.*

It is not known whether BARACLUDE will reduce your chances of getting liver cancer or liver damage (cirrhosis), which may be caused by chronic HBV infection.

Please see Indication and Important Safety Information below, including Boxed WARNINGS.

Not an actual patient.

Not an actual patient quote.

My doctor says that BARACLUDE may improve the condition of my liver.*

It is not known whether BARACLUDE will reduce your chances of getting liver cancer or liver damage (cirrhosis), which may be caused by chronic HBV infection.

Please see Indication and Important Safety Information below, including Boxed WARNINGS.

Not an actual patient.

Not an actual patient quote.

How to take
BARACLUDE® (entecavir)

Your chronic hepatitis B (CHB) A condition that occurs when one is infected with hepatitis B virus for more than 6 months. Often referred to as a "silent" disease, the virus infects the liver, damaging it over time, often without any symptoms. may get worse if you stop taking BARACLUDE (entecavir), so it is important to take BARACLUDE exactly as your doctor tells you.

Your doctor should always be your main source of information about your health and your chronic hepatitis B therapy.

Act Now! Partner with your doctor

Even if you have no symptoms, chronic hepatitis B can become serious at any time. See your doctor regularly to monitor your health.

Download questions to ask your doctor

When taking BARACLUDE (entecavir) for chronic hepatitis B therapy:

  • Take the exact dose that your doctor prescribed for you. BARACLUDE can be taken as a tablet (pill) or liquid. The liquid comes with a spoon to help you measure the dose.
  • Take BARACLUDE on an empty stomach. This means taking your dose at least 2 hours after a meal and at least 2 hours before your next one.
  • Take BARACLUDE exactly as prescribed by your doctor. If you have a regular routine for taking your medicine, there is less chance of missing a dose.
  • Do not change your dose or stop taking BARACLUDE without talking to your healthcare provider. Your hepatitis B virus infection may get worse if you stop taking BARACLUDE. This usually happens within 6 months after stopping BARACLUDE. Your healthcare provider should monitor your health and do regular blood tests to check your liver if you stop taking BARACLUDE.
  • If you take too much BARACLUDE, call your healthcare provider or go to the nearest emergency room right away.
  • If you forget to take BARACLUDE, take it as soon as you remember and then take your next dose at its regular time. If it is almost time for your next dose, skip the missed dose. Do not take two doses at the same time. Call your healthcare provider or pharmacist if you are not sure what to do.
  • Remain under your doctor's care. If you have questions about your chronic hepatitis B therapy or notice any new or unusual symptoms, call your doctor right away. If you have any changes in your health or medicines, talk to your doctor.
  • Do not run out of BARACLUDE. When your supply of BARACLUDE starts to run low, call your healthcare provider or pharmacy for a refill.

Tips for remembering to take BARACLUDE (entecavir) every day

It can be easy to forget to take BARACLUDE if you have no symptoms. However, not taking BARACLUDE exactly as your doctor says may make your symptoms worse. These tips may help you follow your doctor's instructions:

  • Take BARACLUDE at the same time every day. For example, take your medicine right before brushing your teeth or setting your alarm clock.
  • Put a reminder note in a place where you will be sure to see it, such as on your medicine cabinet or refrigerator.
  • Set an alarm on your cell phone to alert you when it's time to take your medicine.
  • Use a pillbox with sections for each day of the week, or keep a "medicine calendar" near your medicine bottle. Make a note each time you take a dose of BARACLUDE.

Learn more about managing your chronic hepatitis B

Starter Brochure

Read “Getting Started,” a helpful guide for patients taking BARACLUDE® (entecavir).

CLICK to download brochure.

Treatment Tracker

Record and track your lab test results to help you and your doctor manage your chronic hepatitis B.

CLICK to download tracker brochure.

Important Safety Information:

Selected Important Safety Information

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What is the most important information I should know about BARACLUDE® (entecavir)?

  •   Your hepatitis B virus infection may get worse if you stop taking BARACLUDE. This usually happens within 6 months after stopping BARACLUDE. Take BARACLUDE exactly as prescribed; do not run out of your medicine or stop taking BARACLUDE without talking to your healthcare provider. Your healthcare provider should monitor your health and do regular blood tests to check your liver if you stop taking BARACLUDE.
  •   If you have or get HIV infection that is not being treated with medicines while taking BARACLUDE, the HIV virus may develop resistance to certain HIV medicines and become harder to treat. You should get an HIV test before you start taking BARACLUDE and anytime after that when there is a chance you were exposed to HIV.

BARACLUDE can cause serious side effects including:

  •   Lactic acidosis (buildup of acid in the blood). Some people who have taken BARACLUDE or medicines like BARACLUDE have developed a serious condition called lactic acidosis. Lactic acidosis is a serious medical emergency that can cause death and must be treated in the hospital. Reports of lactic acidosis with BARACLUDE generally involved patients who were seriously ill due to their liver disease or other medical condition.
    •   Call your healthcare provider right away if you: feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; have stomach pain with nausea and vomiting; feel cold (especially in your arms and legs); feel dizzy or light-headed; have a fast or irregular heartbeat.
  •   Serious liver problems. Some people who have taken medicines like BARACLUDE have developed serious liver problems called hepatotoxicity, with liver enlargement (hepatomegaly) and fat in the liver (steatosis). Hepatomegaly with steatosis is a serious medical emergency that can cause death.
    •   Call your healthcare provider right away if: your skin or the white part of your eyes turns yellow (jaundice); your urine turns dark; your bowel movements (stools) turn light in color; you don’t feel like eating food for several days or longer; you feel sick to your stomach (nausea); you have lower stomach pain.
  •   If you are female, very overweight, or have been taking nucleoside analogue medicines, like BARACLUDE for a long time, you may be more likely to get lactic acidosis or serious liver problems.

Before you take BARACLUDE, tell your healthcare provider if you:

  •   have kidney problems. Your BARACLUDE dose or schedule may need to be changed.
  •   have received medicine for HBV before. Some people, especially those who have already been treated with certain other medicines for HBV, may develop resistance to BARACLUDE and may have less benefit from treatment. Your healthcare provider will test the level of the hepatitis B virus in your blood.
  •   have any other medical conditions.
  •   are pregnant or plan to become pregnant. It is not known if BARACLUDE will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.
  •   are breast-feeding or plan to breast-feed. It is not known if BARACLUDE can pass into your breast milk. You and your healthcare provider should decide if you will take BARACLUDE or breast-feed.

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

The most common side effects of BARACLUDE include: headache, tiredness, dizziness, and nausea. These are not all the possible side effects of BARACLUDE. For more information, ask your healthcare provider or pharmacist.

Do not change your dose or stop taking BARACLUDE without talking to your healthcare provider. If you forget to take your dose, call your healthcare provider or pharmacist, if you are not sure what to do.

Please see Full Prescribing Information, including “What is the most important information I should know about BARACLUDE?” in the Patient Information section. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Selected Important Safety Information:

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Selected Important Safety Information

  •   If you have or get HIV infection that is not being treated with medicines while taking BARACLUDE, the HIV virus may develop resistance to certain HIV medicines and become harder to treat. You should get an HIV test before you start taking BARACLUDE and anytime after that when there is a chance you were exposed to HIV.

BARACLUDE can cause serious side effects including:

  •   Lactic acidosis (buildup of acid in the blood). Some people who have taken BARACLUDE or medicines like BARACLUDE have developed a serious condition called lactic acidosis. Lactic acidosis is a serious medical emergency that can cause death and must be treated in the hospital. Reports of lactic acidosis with BARACLUDE generally involved patients who were seriously ill due to their liver disease or other medical condition.
    •   Call your healthcare provider right away if you: feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; have stomach pain with nausea and vomiting; feel cold (especially in your arms and legs); feel dizzy or light-headed; have a fast or irregular heartbeat.
  •   Serious liver problems. Some people who have taken medicines like BARACLUDE have developed serious liver problems called hepatotoxicity, with liver enlargement (hepatomegaly) and fat in the liver (steatosis). Hepatomegaly with steatosis is a serious medical emergency that can cause death.